ARA-290, also known as cibinetide and helix B surface peptide (HBSP), is an 11–amino acid chain derived from the beta domain of erythropoietin (EPO). Unlike full EPO, which primarily stimulates red blood cell production, ARA-290 was developed to investigate tissue regeneration, repair, and anti-inflammatory activity without hematopoietic effects.

Chemical Specifications: ARA-290 (Cibinetide)

ARA-290, also widely known by its generic name cibinetide, is an engineered 11-amino acid synthetic peptide derived from the tertiary structure of the helix B domain of erythropoietin (EPO).

1. General Identification

• Primary Name: ARA-290
• International Nonproprietary Name (INN): Cibinetide
• Synonyms: Pyroglutamate Helix B Surface Peptide (PHBSP), pHBSP, ARA 290
• CAS Registry Number: 1208243-50-8 (Free base)
• PubChem CID: 91810664
• DrugBank ID: DB13006
• ChEMBL ID: CHEMBL3545305
• UNII: 9W5677JKDA